RESEARCHER PROFILE Associate Professor Joy Wolfram
Group Leader, Australian Institute for Bioengineering and Nanotechnology,
School of Chemical Engineering,
University of Queensland
Brisbane, Australia
Filmed in Brisbane, Queensland | June 2024
Triple-negative breast cancer is aggressive, harder to treat and – for the 2500 Australian women who are diagnosed each year – the disease is more likely to spread to other organs and result in death.
Associate Professor Joy Wolfram, leading a nanomedicine and extracellular vesicle research program with the goal of developing innovative approaches that bring the next generation of treatments and diagnostics directly to the clinic, says this is partially because triple negative breast cancer cells are able to hijack a messaging network in our bodies and convince the immune system to ignore the problem.
Extracellular vesicles are the body’s text messages: little fat bubbles that carry vital information and cargo between cells. However, we know little about how these messengers move about. Understanding this process could be key to developing new diagnostic and therapeutic approaches for diseases such as cancer.
Assoc Prof Wolfram has joint appointments in the School of Chemical Engineering and the Australian Institute for Bioengineering and Nanotechnology at The University of Queensland, and through her work at the AIBN, she aims to develop a new paradigm of therapeutics (using nanotechnology and cell products) to treat life-threatening diseases that are major causes of death globally, including cardiovascular disease, kidney disease, and breast cancer.
It is hoped this will save lives by manufacturing at scale. In so doing, deliver national manufacturing innovation and a skilled workforce by working with a multidisciplinary team and industry partners to position Australia as a global leader in extracellular vesicle medicine.
Her particular focus areas are understanding the role of extracellular vesicles in cancer immunoevasion and metastasis, developing improved methods for extracellular vesicle isolation from human biofluids, and designing hybrid drug delivery systems with extracellular vesicle and synthetic components for a ‘best-of-both-worlds’ approach to treat cardiovascular disease and chronic kidney disease.
Her work has so far appeared in more than 80 journal publications and has received more than 30 awards from eight countries, including the 2016 Amgen Scholars Ten to Watch List (best and brightest up-and-comers in science and medicine across 42 countries), the 2019 Forbes 30 under 30 list in Health Care in the United States/Canada, the 2019 shortlist for the Nature Research Award for Inspiring Science (one of ten worldwide), and the 2021 Finnish Expat of the Year.
Assoc Prof Wolfram is currently funded by Australia’s National Breast Cancer Foundation, Health Translation Queensland, Mayo Clinic and Australian Government’s NHMRC.
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Impact of NextSense Institute Research in the field of sensory disabilities
NextSense has a 165 year history of providing services and education for individuals with sensory impairments. With the support of donations, NextSense provides vital support for children and adults, more cochlear implants than any other service in Australia, and is a world leader for research, technology and professional education in the fields of visions and hearing loss.
NextSense clinicians are actively involved in a number of leading research projects—both independently and in collaboration with local and international organisations. The NextSense Institute, part of NextSense is Australia’s leading centre for research and professional education in the field of sensory disabilities.
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Stem cell therapies for enteric neuropathies
Dr Stamp is a Group Leader in the Department of Anatomy and Physiology at the University of Melbourne, Australia. Dr Stamp’s PhD research (with Prof Martin Pera, Monash University) focused on the derivation of hepatopancreatic progenitors from human embryonic stem cells. He then joined the lab of Dr Don Newgreen at the Murdoch Childrens Research Institute where he began working on development of the enteric nervous system (ENS), before joining Prof Heather Young’s lab at the University of Melbourne, where he focused on developing a stem cell therapy to treat gut motility disorders such as the paediatric enteric neuropathy Hirschprung disease.
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Role of Community Paramedicine in Non-Emergency Presentations
Dr Robbie King is a Lecturer in paramedicine and researcher at the Australian Catholic University (ACU) Brisbane. He also continues to provide clinical care as a registered paramedic for community members served by a jurisdictional ambulance service. Dr King has gained significant experience working in an advanced practice, community paramedic style role, holding expert clinical insight into the nuances of paramedic-led community-based healthcare for non-emergency presentations. This often involves adopting a biopsychosocial approach, rather than following the biomedical model more associated with emergency medicine and paramedic culture.
