RESEARCHER PROFILE Associate Professor Joy Wolfram
Group Leader, Australian Institute for Bioengineering and Nanotechnology,
School of Chemical Engineering,
University of Queensland
Brisbane, Australia
Filmed in Brisbane, Queensland | June 2024
Triple-negative breast cancer is aggressive, harder to treat and – for the 2500 Australian women who are diagnosed each year – the disease is more likely to spread to other organs and result in death.
Associate Professor Joy Wolfram, leading a nanomedicine and extracellular vesicle research program with the goal of developing innovative approaches that bring the next generation of treatments and diagnostics directly to the clinic, says this is partially because triple negative breast cancer cells are able to hijack a messaging network in our bodies and convince the immune system to ignore the problem.
Extracellular vesicles are the body’s text messages: little fat bubbles that carry vital information and cargo between cells. However, we know little about how these messengers move about. Understanding this process could be key to developing new diagnostic and therapeutic approaches for diseases such as cancer.
Assoc Prof Wolfram has joint appointments in the School of Chemical Engineering and the Australian Institute for Bioengineering and Nanotechnology at The University of Queensland, and through her work at the AIBN, she aims to develop a new paradigm of therapeutics (using nanotechnology and cell products) to treat life-threatening diseases that are major causes of death globally, including cardiovascular disease, kidney disease, and breast cancer.
It is hoped this will save lives by manufacturing at scale. In so doing, deliver national manufacturing innovation and a skilled workforce by working with a multidisciplinary team and industry partners to position Australia as a global leader in extracellular vesicle medicine.
Her particular focus areas are understanding the role of extracellular vesicles in cancer immunoevasion and metastasis, developing improved methods for extracellular vesicle isolation from human biofluids, and designing hybrid drug delivery systems with extracellular vesicle and synthetic components for a ‘best-of-both-worlds’ approach to treat cardiovascular disease and chronic kidney disease.
Her work has so far appeared in more than 80 journal publications and has received more than 30 awards from eight countries, including the 2016 Amgen Scholars Ten to Watch List (best and brightest up-and-comers in science and medicine across 42 countries), the 2019 Forbes 30 under 30 list in Health Care in the United States/Canada, the 2019 shortlist for the Nature Research Award for Inspiring Science (one of ten worldwide), and the 2021 Finnish Expat of the Year.
Assoc Prof Wolfram is currently funded by Australia’s National Breast Cancer Foundation, Health Translation Queensland, Mayo Clinic and Australian Government’s NHMRC.
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Therapies for chronic myeloid leukaemia
Professor Tim Hughes is an international expert in the biology and treatment of leukaemia. He led the establishment of the molecular response criteria that are used world-wide to measure response in chronic myeloid leukaemia (CML) and has led many of the key Global and National trials. His group has successfully developed predictive bioassays and molecular targets that influence the way CML patients are managed world-wide. He has published over 350 papers that have been cited over 65,000 times.
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Development of novel analytical and diagnostic tools using nanotechnology and microfluidics
Dr Alain Wuethrich is an NHMRC Emerging Leader fellow and ARC DECRA awardee at the Australian Institute for Bioengineering and Nanotechnology.
Hailing from Switzerland, research focuses on the development of novel analytical and diagnostic tools that harness nanotechnology and microfluidics; two rapidly growing fields with high potential to provide diagnostic solutions needed for precision medicine.
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Life-changing donor milk for preterm babies
Dr Laura Klein is National Milk Research Leader at Australian Red Cross Lifeblood. Australian Red Cross Lifeblood is funded by Australian governments to provide life-giving blood, plasma, and transplantation and biological products.
Dr Klein works with clinicians and researchers across Australia to understand how donated breast milk can be used to improve outcomes for vulnerable babies. She’s passionate about generating evidence to improve the products and services that milk banks provide to donors and the families who receive donated breast milk.
