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CASE STUDY Link between levels of extracellular vesicles in the blood and tissue damage caused by diseases

A landmark study led by WEHI and La Trobe University has found a potential new diagnostic marker that could be used to better detect the level of tissue damage in our bodies.

This study revealed, for the first time, a link between levels of EVs in the blood and tissue damage caused by diseases such as leukaemia.

Researchers hope to leverage the critical new insight to develop a blood test to monitor cancer patients with tissue damage, which could, in future, enhance treatment strategies for blood cancers and other diseases.

Environmental exposure to function of lung epithelial stem cell biology

Dr Clare Weeden has recently commenced as a Laboratory Head at WEHI in 2025, supported by the CSL Centenary Fellowship.

Dr Weeden specialises in lung epithelial cell biology in the context of homeostasis, inflammation, and lung cancer, particularly in people who don’t smoke. Her work endeavours to understand how past environmental exposures shape the responses of lung cells and the molecular mechanisms underlying this cellular recall, with the aim to develop novel early detection strategies for lung disease.

Pregnancy in women with chronic kidney disease

Professor Shilpanjali Jesudason is an academic nephrologist and Head of Department at the Royal Adelaide Hospital’s Central Northern Adelaide Renal and Transplant Service, South Australia. 

From 2017-2020, she was the Clinical Director of Kidney Health Australia, the peak body for patients with kidney disease. In this role she developed a passion for advancing kidney disease education in primary care. 

Next-generation NK cell-based immunotherapies for hard-to-treat cancers

Associate Professor Fernando Guimaraes is an internationally recognised leader in cancer immunotherapy and natural killer (NK) cell biology. Based at The University of Queensland, he leads innovative research focused on developing next-generation NK cell-based immunotherapies for hard-to-treat cancers, including sarcomas and neuroblastoma.

Food and fasting periods as medicine to prevent disease

Professor Leonie Heilbronn is based at the South Australian Health and Medical Research Institute (SAHMRI), where she leads the Obesity and Metabolism laboratory. Her research is at the interface between basic and clinical science. She is internationally recognised for her work in nutritional modulation in humans and has made major contributions to our current understanding of mechanisms underlying conditions such as insulin resistance, particularly inflammation and lipid metabolism. She has also contributed significantly to current concepts of caloric restriction (CR), intermittent fasting (IF) and time restricted eating (TRE) in humans. She has published more than 110 peer reviewed papers in scientific journals and is an Associate Editor of Obesity, and Obesity Research and Clinical Practice.

Genomics and rationally targeted therapies in Acute Lymphoblastic Leukaemia

Prof Deborah White’s research focus is genomics and rationally targeted therapies in Acute Lymphoblastic Leukaemia (ALL) and Chronic Myeloid Leukaemia (CML) and she holds peer reviewed grants from: The William Lawrence and Blanche Hughes Foundation and the Leukemia Lymphoma Society (USA), the NHMRC, the Leukaemia Foundation Australia (LFA), Channel 7, Cancer Australia, Tour de Cure and the Cancer Council SA (CCSA). Professor White has presented more than 170 papers at scientific meetings, and authored more than 100 scientific publications as well as being an inventor on several international patents.

Infections and other lung diseases using models of human lung tissue grown from stem cells

Dr Rhiannon Werder is a Team Leader at Murdoch Children’s Research Institute leading a multidisciplinary team, combining expertise in stem cell biology and immunology, to develop new therapies for lung diseases. Her research centres around induced pluripotent stem cells to investigate respiratory diseases, spanning acute respiratory infections to chronic lung diseases. Using stem cells, Dr Werder’s team creates models of human lung tissue. With these models, Dr Werder is investigating how human-specific pathogens infect different regions of the lung, the ensuing immune responses, and how the lung repairs itself after infections, especially in people with preexisting lung diseases.

Blister management and impact on firefighters

David Burns, a Senior Paramedic with LifeAid, a private paramedicine company in Victoria and, has a diverse background in healthcare. He began his career as a registered nurse, progressing to critical care nursing specialising in liver transplants and cardiovascular surgery.

At the Australasian College of Paramedicine International Conference, David presented research focused on the foot care of firefighters during prolonged bushfire campaigns. During the 2019-2020 bushfires, over 10,000 firefighters sought care, with nearly 50% requiring attention for foot-related issues. David emphasised that inadequate foot care could bench firefighters for up to 10 days, diminishing their ability to protect communities and critical infrastructure. Recognising the economic benefits of prioritising firefighter health, David advocates that ensuring their well-being allows communities to recover effectively and enhances safety for all involved in firefighting efforts.

Patient reported outcomes in the diagnosis and treatment of lymphoma

Dr. Elizabeth Goodall (BMedSci Hons, MBBS Hons, FRACP, FRCPA) is a PhD student and early career researcher with La Trobe University and the Olivia Newton John Cancer Research Institute (ONJCRI), and Haematologist at Austin Health and Monash Health, Melbourne.

Her specific interest in how patients experience their illness and treatment forms the basis for her research in improving patient outcomes. This research comes at a pivotal time in modern lymphoma management with an ever-increasing number of treatment options available and renewed focus on each patient’s journey.

Supportive care for people living with or beyond cancer treatment

Dr Hannah Wardill is a Hospital Research Foundation Fellow and lead of the Supportive Oncology Research Group (SORG), in the School of Biomedicine, University of Adelaide and Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute (SAHMRI). She is an Executive Board Member of the Multinational Association for Supportive Care in Cancer / International Society for Oral Oncology (MASCC/ISOO) and Chair of both MASCC/ISOO Patient Partnership Committee & the Palliative Care Clinical Studies Collaborative (PaCCSC) Cancer Symptom Trials (Gut Dysfunction Node; supported by Cancer Australia).

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