IMMUNE MECHANISMS OF COELIAC DISEASE AND GLUTEN-RELATED DISORDERS
With
Professor Jason Tye-Din,
Director, Snow Centre for Immune Health &
Head of the Coeliac Research Laboratory at WEHI &
Gastroenterologist, Royal Melbourne Hospital &
Clinician Researcher,
Melbourne, Australia
RESEARCHER PROFILE
Filmed in Melbourne | September 2026
Professor Jason Tye-Din is head of the Coeliac Research Laboratory at WEHI and a gastroenterologist at the Royal Melbourne Hospital. His expertise spans the immune mechanisms of coeliac disease, clinical care of gluten-related disorders, diagnostic discovery and pre-clinical and clinical drug development. His work aims to improve the health and quality of life of people suffering gastrointestinal immune diseases, particularly those caused by gluten and other foods.
Professor Tye-Din is a Principal Research Fellow at the University of Melbourne, Honorary Research Fellow at the Murdoch Children’s Research Institute and is involved in multiple leadership and advisory roles, including to the World Health Organisation and industry.
As a recognised leader in immunology and translational science, Professor Tye-Din’s research has been widely published. Most recently, he led the development of a ground-breaking blood test that has the potential to transform the way coeliac disease is diagnosed.
Source: Supplied
https://orcid.org/0000-0001-7687-9654 -
Therapies for chronic myeloid leukaemia
Professor Tim Hughes is an international expert in the biology and treatment of leukaemia. He led the establishment of the molecular response criteria that are used world-wide to measure response in chronic myeloid leukaemia (CML) and has led many of the key Global and National trials. His group has successfully developed predictive bioassays and molecular targets that influence the way CML patients are managed world-wide. He has published over 350 papers that have been cited over 65,000 times.
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Infections and other lung diseases using models of human lung tissue grown from stem cells
Dr Rhiannon Werder is a Team Leader at Murdoch Children’s Research Institute leading a multidisciplinary team, combining expertise in stem cell biology and immunology, to develop new therapies for lung diseases. Her research centres around induced pluripotent stem cells to investigate respiratory diseases, spanning acute respiratory infections to chronic lung diseases. Using stem cells, Dr Werder’s team creates models of human lung tissue. With these models, Dr Werder is investigating how human-specific pathogens infect different regions of the lung, the ensuing immune responses, and how the lung repairs itself after infections, especially in people with preexisting lung diseases.
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Inner ear organoids for the study of human hearing and balance
Dr Jackie Ogier is an auditory neuroscientist, with a research focus on the molecular biology of hair cells, the specialised sensory receptors in the ear that detect sound and balance. She is a postdoctoral research fellow in the laboratory of A/Prof Bryony Nayagam, supported by a prestigious Passe and Williams foundation fellowship.
Dr Ogier’s experience broadly spans the genetics of hearing loss, disease modelling, micro dissection, primary cell culture, stem cell culture, organoids, and proteomics. Overall, she aims to generate knowledge of hearing and vestibular sensory biology.
