TYROSINE KINASES IN CANCER RECURRENCE
With
Dr Yu Yu
Program Lead, Curtin Medical Research Institute &
Senior Research Fellow, Curtin Medical School,
Curtin University, Perth, Western Australia
RESEARCHER PROFILE
Filmed in Perth, Australia | July 2025
Dr Yu Yu completed her PhD at Faculty of Medicine, University of Sydney in experimental therapeutics for cancer. She then pursued postdoctoral training at the Richard W. TeLinde Gynecologic Pathology Laboratory, Johns Hopkins University School of Medicine, USA with a focus on understanding the treatment for recurrent ovarian tumour.
Dr Yu Yu leads the Oncology and Gynaecology Research Program at Curtin Medical Research Institute . Dr Yu is also a senior research fellow at Curtin Medical School.
Dr Yu Yu has a strong expertise in developing molecular and cellular therapeutics for cancer. She is a former NHMRC Peter Doherty Fellow and Raine/Robson Fellow. Her studies focused on recurrent cancers, with interests in biomarker and therapeutics development.
Ovarian cancer is one of the deadliest gynaecologic cancers. There are ~300,000 new cases of ovarian cancer worldwide each year. Less than half of women diagnosed survive 5-years after diagnosis. Platinum-based chemotherapy is used to treat ovarian cancers and a variety of other solid cancers. The National Cancer Institute reports 20% of cancer patients worldwide (3.6 million people) receive a platinum-based drug as part of treatment. However, ~20-50% do not respond because of intrinsic resistance. Currently, there is no way to predict response prior to starting platinum chemotherapy.
Dr Yu Yu’s laboratory is working on better ways to treat cancers, particularly ovarian cancers which are resistant to conventional chemotherapy. The aims are for better informed treatment choice and reducing unnecessary exposure to ineffective chemotherapy and its potential adverse effects.
Collaboration partners include St John of God Hospital and King Edward Memorial Hospital, both in Western Australia. Funding for Dr Yu Yu’s research comes from WA Department of Health’s Future Health and Innovation Research Fund, Raine Medical Research Foundation and Endometriosis Foundation of America.
Source: Supplied and adapted
https://orcid.org/0000-0002-0209-0586
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In his father’s footsteps as a kidney transplant specialist
Since he was a young child, Dr Collins, has been interested in kidney failure and kidney transplants in particular. His father was also a kidney specialist, and he used to sit by the phone when his father, was on call and ringing people who were being offered a kidney transplant. The joy in their voices through this interaction created a lasting and profound impact on Dr Collins. This carried through his career and today he continues to seek better outcomes for Kidney patients.
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Impact of Leukaemia Foundation’s Research Funding into Blood Cancer
Bill Stavreski is the Head of Research at the Leukaemia Foundation who talks about the research impact in recent years. The Foundation itself marks its 25th anniversary in 2025, having funded a wide range of health and medical research since 2000. With a focus on basic science, health services research, treatment, and care, the organisation has invested nearly $90 million (adjusted in current dollars terms) in approximately 370 research grants over the years.
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World-first clinical trial improves patient outcomes for kidney transplants (2023)
A world-first clinical trial conducted at the Royal Adelaide Hospital (RAH) and at hospitals across Australia and New Zealand has identified the best fluid treatment to reduce the risk of patients requiring dialysis after a kidney transplant.
Around one in three people who receive a kidney transplant suffer delayed graft function, which means the transplant doesn’t work immediately and they require dialysis.
The lead-author of the study, was Royal Adelaide Hospital Nephrologist and University of Adelaide researcher, Dr Michael Collins.
