HYPERTENSION AND THE GUT MICROBIOME: USING GUT MICROBES TO REDUCE BLOOD PRESSURE
Professor Francine Marques
Professor of Genetics and Genomics
Monash University, Victoria, Australia
RESEARCHER PROFILE (Filmed in Clayton, Victoria | December 2024)
Professor Francine Marques is an National Health and Medical Research Council Emerging Leader, Viertel Charitable Foundation, and National Heart Foundation Fellow.
She leads the Hypertension Research Laboratory at Monash University and has published more than 120 peer-reviewed papers in journals such as Nature Reviews Cardiology, Nature Medicine, Nature Cardiovascular Research, and Circulation.
As a researcher Professor Marques has secured over $10 million in competitive funding as a principal investigator. She has won 31 awards, including the 2019 American Heart Association Hypertension Council Goldblatt Award, the 2020 High Blood Pressure Research Council of Australia and 2021 International Society of Hypertension Mid-Career Awards, the 2021 Australian Academy of Science Gottschalk Medal, and the 2024 Australian Society of Medical Research Peter Doherty Leading Light Award, and was a finalist for 12 awards, including the Eureka Prize Emerging Leader in Science.
Her research team aims to build exceptional scientists that help improve cardiovascular health, using translational approaches to lower blood pressure via the gut microbiome. Professor Marques is also passionate about equity, diversity and inclusion (EDI) and helping communities change the current culture of research.
She has led research identifying intrinsic equity issues in the cardiovascular research community in Australia (https://pubmed.ncbi.nlm.nih.gov/32839116/), followed by research to find solutions for these issues (https://pubmed.ncbi.nlm.nih.gov/35577952/), resulting in the 2021 Women’s Agenda Emerging Leader in STEM award.
Outside work, Francine enjoys baking, travelling, spending time with family, friends and her dogs, and reading books.
https://orcid.org/0000-0003-4920-9991
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Links investigated between poor sleep and onset of dementia
Watch Samantha Bramich, a PHD candidate at the Wicking Dementia Research and Education Centre, University of Tasmania talk on identify the prevalence of rapid eye movement sleep behaviour disorder (RBD) in Tasmania and how poor sleep contributes to the onset of dementia and other diseases.
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CASE STUDY High blood pressure and shorter sleep may worsen brain decline
People with high blood pressure who also lack sleep may be at increased risk of reduced cognitive performance and greater brain injury, Monash University research has found.
Published in the Journal of the American Heart Association, researchers assessed whether the combined effect of hypertension and short sleep duration had a negative impact on brain health.
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CASE STUDY Link between levels of extracellular vesicles in the blood and tissue damage caused by diseases
A landmark study led by WEHI and La Trobe University has found a potential new diagnostic marker that could be used to better detect the level of tissue damage in our bodies.
This study revealed, for the first time, a link between levels of EVs in the blood and tissue damage caused by diseases such as leukaemia.
Researchers hope to leverage the critical new insight to develop a blood test to monitor cancer patients with tissue damage, which could, in future, enhance treatment strategies for blood cancers and other diseases.
