DEVELOPMENT OF NOVEL ANALYTICAL AND DIAGNOSTIC TOOLS USING NANOTECHNOLOGY AND MICROFLUIDICS
With
Dr Alain Wuethrich
NHMRC Emerging Leader Fellow
Australian Institute for Bioengineering and Nanotechnology,
The University of Queensland
Brisbane, Australia
RESEARCHER PROFILE
Filmed in Brisbane | June 2025
Dr Alain Wuethrich is an NHMRC Emerging Leader fellow and ARC DECRA awardee at the Australian Institute for Bioengineering and Nanotechnology.
Hailing from Switzerland, research focuses on the development of novel analytical and diagnostic tools that harness nanotechnology and microfluidics; two rapidly growing fields with high potential to provide diagnostic solutions needed for precision medicine.
A feature of his work has been the ability to translate discoveries at the nanoscale into highly innovative diagnostics that enable the precise study of biomolecular aberrations in cancer, infectious diseases, and human immune system.
His particular research expertise lies in:
– Liquid biopsy
– Electrohydrodynamics
– Surface-enhanced Raman spectroscopy
– Nanotechnology
– Diagnostics
Dr Wuethrich held positions in international pharmaceutical companies and became lead inventor on a European patent.
He has actively engaged with national and international companies to translate diagnostic nanotechnologies. His network of national and international collaborators include the Princess Alexandra Hospital, UQ Diamantina Institute, UQ Centre for Clinical Research, QIMR Berghofer, and the Dana-Farber Cancer Institute.
Since 2017 he has provided continuous research mentoring to the group and has supervised more than 30 postgraduate and graduate students in nanotechnological strategies to detect cancer and other diseases.
In May 2024 Dr Wuethrich won a $1.6 million NHMRC Emerging Leader 2 grant to develop digital nanotechnology capable of detecting trace immune dysregulation from a pin-prick of blood.
He says understanding immune dysregulation is crucial for addressing emerging diseases like Long Covid and for future-proofing immune-modulating mRNA vaccines.
“The technology we have in mind will be 1000 times more sensitive than conventional methods,” Dr Wuethrich said.
“Hopefully, this will lead to a better understanding, diagnosis, and treatment of diseases like long COVID, and the development of personalised vaccines with greatly reduced side effects.”
Dr Wuethrich is one of two Investigator Grant winners currently working with Professor Matt Trau.
Source: Supplied
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DNA repair on the Fanconi anaemia pathway
Associate Professor Wayne Crismani is an internationally recognised expert in DNA repair, with a particular focus on Fanconi anaemia (FA)—a cancer-predisposition and bone marrow failure syndrome marked by extreme sensitivity to DNA damage. Based at St Vincent’s Institute in Melbourne, he leads a research program dedicated to understanding the genetic, cellular, and reproductive consequences of FA. He is currently supported by a Victorian Cancer Agency Mid-Career Fellowship and funding from the National Health and Medical Research Council.
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Prescribing exercise to regional population with cardiovascular disease & diabetes
Associate Professor Gordon’s research is aimed at determining the optimal methods of prescribing and implementing exercise as part of the health care plan for people with cardiovascular disease and diabetes. Specifically, he is leading work to determine if and how the components of exercise can be considered as a whole for prescribing exercise to generate health benefits. This is important to overcome the series of barriers that people living in rural and regional areas experience when trying to become active.
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Exercise therapy for metabolic dysfunction-associated steatotic liver disease
Dr Shelley Keating is a Senior Lecturer in Clinical Exercise Physiology and Accredited Exercise Physiologist from the School of Human Movement and Nutrition Sciences at the University of Queensland. With a strong grounding in exercise metabolism and body composition, Dr Keating’s research centres on the utility of exercise as a therapy for obesity and related cardiometabolic conditions, notably metabolic dysfunction-associated steatotic liver disease (MASLD).
