DNA REPAIR ON THE FANCONI ANAEMIA PATHWAY
Associate Professor Wayne Crismani
Laboratory Head, DNA Repair & Recombination
St Vincent’s Institute of Medical Research,
Melbourne, Australia
RESEARCHER PROFILE
Filmed in Melbourne, Australia | August 2025
Associate Professor Wayne Crismani is an internationally recognised expert in DNA repair, with a particular focus on Fanconi anaemia (FA)—a cancer-predisposition and bone marrow failure syndrome marked by extreme sensitivity to DNA damage. Based at St Vincent’s Institute in Melbourne, he leads a research program dedicated to understanding the genetic, cellular, and reproductive consequences of FA. He is currently supported by a Victorian Cancer Agency Mid-Career Fellowship and funding from the National Health and Medical Research Council.
His career spans academia and industry across Australia, Europe, and the United States. He has contributed to several advances in FA genetics, including the identification of new functions of FA genes, particularly in reproduction, development of isogenic cell models, and use of high-throughput functional and screening assays. He has also demonstrated that FA is under-diagnosed in Australia, which has major consequences for these individuals and for the public healthcare system. His research has been published in top-tier journals and underpins several patents, including technologies that have been successfully licensed.
Associate Professor Crismani also leads multidisciplinary studies investigating fertility and cancer risk in individuals with FA. These include the first systematic study of biological parenthood and assisted reproductive technologies in adults with FA, and efforts to identify early biomarkers of oral cancer in this high-risk group. His work is conducted in close collaboration with scientists, clinicians, fertility specialists, and patient advocates. He co-founded Fanconi Anaemia Support Australasia with a group of families in 2019 and continues to organise scientific and social events for the FA community.
He works with international FA registries, research consortia, and the Fanconi Cancer Foundation to ensure research findings inform real-world care. His program bridges molecular biology, reproductive health, and translational science, with the goal of improving health outcomes for people with FA and genetic conditions.
Source: Supplied
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Next Generation Condom Contraception, Dr David Shepherd
Dr David Shepherd is a Lead Production Engineer and Materials Specialist at Eudaemon Technologies. His journey began at the University of Wollongong, where he pursued advanced studies and eventually obtained a PhD under the guidance of a distinguished professor. His research initially focused on actuating materials and artificial muscles, particularly centred around hydrogel materials. These early explorations have seamlessly evolved into his current focus on utilising hydrogels in the realm of sexual reproductive health, with a specific emphasis on developing innovative hydrogel condoms.
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Newborn screening for congenital hypothyroidism
Assoc Prof Jack is passionate about the health and wellbeing of children and adolescents, with diverse research areas including the impacts of family friendly workplace initiatives, screening and management of thyroid disorders in infants and children. She supports her First Nations colleagues on Indigenous-led research projects funded by the Medical Research Future Fund, aiming to improve the social and emotional wellbeing of First Nations Children. Through her clinical and academic roles, Assoc Prof Jack hopes to make a positive difference to the health and well-being of children and their families.
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Professor Ramon Shaban
PROFESSOR RAMON SHABAN, CLINICAL CHAIR
COMMUNICABLE DISEASE CONTROL AND INFECTION PREVENTION
WESTERN HEALTH PRECINCT, SYDNEY, AUSTRALIA
