RESEARCHER PROFILE
Dr Erin Brazel
University of Adelaide
Filmed February 2024
Dr Erin Brazel has a background in molecular and translational microbiology, with a focus on developing new ways of preventing and treating bacterial diseases. Recently Dr Brazel has been awarded a Junior Fellowship by the Passe & Williams Memorial Foundation.
The fellowship enables outstanding individuals to obtain postdoctoral training under the supervision of an experienced clinical or scientific researcher, with the view to establishing a research career in Otolaryngology, Head and Neck Surgery in Australia and/or New Zealand.
The fellowship will support research on bacterial vaccines in a joint GPN Vaccines Ltd and the University of Adelaide project to explore combination vaccines for ear infections using Gamma-PN.
Bacterial ear infections are the most common bacterial disease affecting children. In Australia, episodes range from 1-2.4 million each year, affecting over 600,000 individuals, with 40% of these children experiencing six or more recurrences before the age of eight. Persistent cases can result in hearing loss and learning difficulties, leading to developmental delays and impacts on psychosocial health. Chronic ear infections have also been linked to increased rates of obesity during childhood and Later in life, which may be a result of prolonged antibiotic usage.
With antibiotic resistant superbugs projected to kill 10 million people each year by 2050, new ways of combatting disease are urgently required. A major focus of Dr Brazel’s research is the development of new vaccines to address emerging and existing pathogens that threaten global health and biosecurity. Vaccines are an important tool for reducing disease caused by antimicrobial resistant pathogens, the spread of resistant bacteria, and to reduce antimicrobial use in health and animal care.
Dr Brazel has contributed to the design and preclinical testing of many next generation vaccine candidates, including the current lead candidate (Gamma-PN3). This vaccine is currently being tested in a first-in-human Phase 1 clinical trial (commenced January 2023).
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Healthcare associated infection prevention
Professor Philip Russo is an internationally regarded expert in healthcare associated infection prevention, and led the recently completed the Australian National Healthcare Associated Infection Point Prevalence Survey, the first in Australia for 34 years. He is also Past President of the Australasian College for Infection Prevention and Control (ACIPC), the peak body for Infection Prevention and Control professionals in the Australasian region.
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Pathogenicity, modelling & treatment of inherited retinal Stargardt disease
Dr Di Huang is a Research Associate at the Lions Eye Institute (LEI), working with A/Professor Fred Chen and Dr Sam McLenachan. Her research focuses on developing a robust platform of retinal pigment epithelium cells and retinal organoids derived from patient-specific induced pluripotent stem cells to model inherited retinal diseases, particularly Stargardt disease (STGD1).
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Pregnancy in women with chronic kidney disease
Professor Shilpanjali Jesudason is an academic nephrologist and Head of Department at the Royal Adelaide Hospital’s Central Northern Adelaide Renal and Transplant Service, South Australia.
From 2017-2020, she was the Clinical Director of Kidney Health Australia, the peak body for patients with kidney disease. In this role she developed a passion for advancing kidney disease education in primary care.
