CORNEAL AND OCULAR SURFACE IMMUNOLOGY AND REGENERATION
Associate Professor Holly Chinnery,
Inaugural Ian Constable Research Fellow,
Lions Eye Institute,
UWA Optometry at The University of Western Australia
RESEARCHER PROFILE
Filmed in Perth, Western Australia | November 2024
Associate Professor Holly Chinnery is a teaching and research academic in the field of corneal and ocular immunology who has spent her career teaching anatomy and immunology to Optometry students at the University of Melbourne and now at UWA, while also leading a Corneal and Ocular Immunology Research team.
Career highlights include:
– Leading a team of students and early career staff over the past 15 years working on corneal and retinal immunology, a co-leading the FrontTear Research Centre with Professor Laura Downie at the University of Melbourne https://www.fronttear.au/
– Receiving NH&MRC Ideas and ARC Discovery Grant funding
– Speaking invitations at Oxford University, University of Birmingham and the Association for Research in Vision and Ophthalmology; and recent publications in PNAS and Nature Reviews Immunology.
Assoc Professor Chinnery’s career in ocular immunology began with a focus on animal models; however, it has recently transitioned into clinical imaging studies involving human research participants. The ability to visualise the immune system and sensory nerves in the human cornea represents a significant advantage in corneal immunology and neuroimmunology research.
This advancement is made possible through a methodology called Functional In Vivo Confocal Microscopy (Fun-IVCM), which enables the observation of immune cell dynamics in the living human eye. Utilising this technology led to a breakthrough in the field of ocular immunology, culminating in a report published in PNAS, a highly prestigious journal, regarding the presence of T cells in the healthy human cornea https://www.pnas.org/doi/full/10.1073/pnas.2217795120.
This finding challenges existing dogmas and is poised to reshape the field of corneal immunology, prompting a reconsideration of previously held beliefs about how the cornea manages inflammation and immune protection, with direct implications for healthy vision.
For the first time, a variety of immune cells can be visualised in the living human cornea, generating a wealth of new questions about immunology, cell biology, and the effects that diseases outside the eye have on immune cells at the eye’s surface.
In her recent appointment at the Lions Eye Institute, Assoc Professor Chinnery aims to establish and support a team of researchers focused on corneal and ocular surface regeneration, which is one of the key research priorities of the Institute.
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DNA repair on the Fanconi anaemia pathway
Associate Professor Wayne Crismani is an internationally recognised expert in DNA repair, with a particular focus on Fanconi anaemia (FA)—a cancer-predisposition and bone marrow failure syndrome marked by extreme sensitivity to DNA damage. Based at St Vincent’s Institute in Melbourne, he leads a research program dedicated to understanding the genetic, cellular, and reproductive consequences of FA. He is currently supported by a Victorian Cancer Agency Mid-Career Fellowship and funding from the National Health and Medical Research Council.
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In his father’s footsteps as a kidney transplant specialist
Since he was a young child, Dr Collins, has been interested in kidney failure and kidney transplants in particular. His father was also a kidney specialist, and he used to sit by the phone when his father, was on call and ringing people who were being offered a kidney transplant. The joy in their voices through this interaction created a lasting and profound impact on Dr Collins. This carried through his career and today he continues to seek better outcomes for Kidney patients.
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Oral administration of insulin for Type 1 Diabetes
Huiwen Pang is a 3rd year PhD candidate in the Australian Institute for Bioengineering and Nanotechnology, University of Queensland, focusing on biomedical health research. Prior to commencing his PhD, Huiwen studied animal genetics in his Masters degree at Huazhong Agriculture University in China.
People with diabetes, especially Type 1 diabetes, largely rely on the insulin injections or insulin pumps to control their high blood glucose levels, which is painful and has a high risk of infections.
Huiwen Pang is conducting research on nano-based drug formulations for Type 1 diabetes treatment, with a focus on using nanomaterials to load insulin for oral administration and employing anti-apoptotic and anti-inflammatory approaches to mitigate damage to beta cells.
