CORNEAL AND OCULAR SURFACE IMMUNOLOGY AND REGENERATION
Associate Professor Holly Chinnery,
Inaugural Ian Constable Research Fellow,
Lions Eye Institute,
UWA Optometry at The University of Western Australia
RESEARCHER PROFILE
Filmed in Perth, Western Australia | November 2024
Associate Professor Holly Chinnery is a teaching and research academic in the field of corneal and ocular immunology who has spent her career teaching anatomy and immunology to Optometry students at the University of Melbourne and now at UWA, while also leading a Corneal and Ocular Immunology Research team.
Career highlights include:
– Leading a team of students and early career staff over the past 15 years working on corneal and retinal immunology, a co-leading the FrontTear Research Centre with Professor Laura Downie at the University of Melbourne https://www.fronttear.au/
– Receiving NH&MRC Ideas and ARC Discovery Grant funding
– Speaking invitations at Oxford University, University of Birmingham and the Association for Research in Vision and Ophthalmology; and recent publications in PNAS and Nature Reviews Immunology.
Assoc Professor Chinnery’s career in ocular immunology began with a focus on animal models; however, it has recently transitioned into clinical imaging studies involving human research participants. The ability to visualise the immune system and sensory nerves in the human cornea represents a significant advantage in corneal immunology and neuroimmunology research.
This advancement is made possible through a methodology called Functional In Vivo Confocal Microscopy (Fun-IVCM), which enables the observation of immune cell dynamics in the living human eye. Utilising this technology led to a breakthrough in the field of ocular immunology, culminating in a report published in PNAS, a highly prestigious journal, regarding the presence of T cells in the healthy human cornea https://www.pnas.org/doi/full/10.1073/pnas.2217795120.
This finding challenges existing dogmas and is poised to reshape the field of corneal immunology, prompting a reconsideration of previously held beliefs about how the cornea manages inflammation and immune protection, with direct implications for healthy vision.
For the first time, a variety of immune cells can be visualised in the living human cornea, generating a wealth of new questions about immunology, cell biology, and the effects that diseases outside the eye have on immune cells at the eye’s surface.
In her recent appointment at the Lions Eye Institute, Assoc Professor Chinnery aims to establish and support a team of researchers focused on corneal and ocular surface regeneration, which is one of the key research priorities of the Institute.
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Lymphoma, Myeloma and Genomics
Professor Dipti Talaulikar is a clinical and laboratory haematologist with expertise in genomics, working at Canberra Health Services, and Professor at ANU. She has a clinical and research interest in lymphoma, myeloma and genomics, and has authored close to 100 peer reviewed papers, including several clinical guidelines that have had a significant impact on clinical practice.
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Next Generation Condom Contraception, Dr Simon Cook
Dr. Simon Cook, Co-Founder and Executive Director of Operations at Eudaemon Technologies, has had a diverse and impactful career journey. Beginning with a background in biotechnology from the University of Wollongong, his focus on bacterial pathogenesis during his PhD led him to study Group A Strep and the streptokinase protein.
Subsequently, Dr. Cook ventured into a unique project funded by the Bill and Melinda Gates Foundation, where he became involved in the development of a next-generation condom to address existing issues such as feel, odour, and taste.
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Role of Community Paramedicine in Non-Emergency Presentations
Dr Robbie King is a Lecturer in paramedicine and researcher at the Australian Catholic University (ACU) Brisbane. He also continues to provide clinical care as a registered paramedic for community members served by a jurisdictional ambulance service. Dr King has gained significant experience working in an advanced practice, community paramedic style role, holding expert clinical insight into the nuances of paramedic-led community-based healthcare for non-emergency presentations. This often involves adopting a biopsychosocial approach, rather than following the biomedical model more associated with emergency medicine and paramedic culture.
