IDENTIFICATION, CHARACTERISATION AND ROLE OF LEADER CELLS IN OVARIAN CANCER PROGRESSION
Dr Maree Bilandzic, Research Group Head
Metastasis Biology & Therapeutics Laboratory
Hudson Institute of Medical Research,
Clayton, Victoria, Australia
RESEARCHER PROFILE
Filmed in Clayton, Victoria, Australia | December 2024
Dr. Maree Bilandzic is a molecular cancer biologist dedicated to advancing the understanding and treatment of ovarian cancer (OC). Her research addresses critical gaps in OC treatment by investigating the mechanisms behind metastasis, chemotherapy resistance, and tumour recurrence. By utilising innovative methodologies and disease-representative models, Dr. Bilandzic has pioneered the identification and characterisation of leader cells (LCs)—a unique, stem-like subpopulation within tumours that plays a crucial role in OC progression.
LCs facilitate “collective invasion,” enabling tumour cells to spread by interacting with their environment and influencing immune responses. Importantly, Dr. Bilandzic’s research demonstrated that these LCs are resistant to standard therapies and become more prevalent following treatment. Despite their significance, there are currently no targeted therapies for LCs, highlighting the urgent need for novel therapeutic strategies.
Her work focuses on meeting the unmet clinical needs of patients with metastatic and therapy-resistant OC. By disrupting LCs, Dr. Bilandzic’s team has shown enhanced chemosensitivity, limited tumor spread, and altered immune responses—demonstrating the therapeutic potential of targeting LCs.
She has over $3.5 million in commercial funding and additional support exceeding $2 million from organisations such as the Ovarian Cancer Research Foundation, CASS Foundation, Fielding Foundation, Equity Trustees and Perpetual Impact grants. Dr. Bilandzic is well-positioned to expand her research into other epithelial cancers, aiming to develop effective treatments that can significantly improve patient outcomes across multiple cancer types. Key areas of focus include understanding LC roles in immune modulation, invasion, metastasis, and chemotherapy resistance.
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Novel therapy for pancreatic cancers, targeting molecular foundation
Dr Michael Lee is an experienced medical oncologist, sub-specialising in gastrointestinal cancers and neuroendocrine tumours at the Peter MacCallum Cancer Centre.
He plays a key role in molecular tumour boards at VCCC Alliance (Victorian Comprehensive Cancer Centre) and MPCCC (Monash Partners Comprehensive Cancer Consortium), ensuring the accurate and effective use of precision medicine in cancer care across the state.
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Supportive care for people living with or beyond cancer treatment
Dr Hannah Wardill is a Hospital Research Foundation Fellow and lead of the Supportive Oncology Research Group (SORG), in the School of Biomedicine, University of Adelaide and Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute (SAHMRI). She is an Executive Board Member of the Multinational Association for Supportive Care in Cancer / International Society for Oral Oncology (MASCC/ISOO) and Chair of both MASCC/ISOO Patient Partnership Committee & the Palliative Care Clinical Studies Collaborative (PaCCSC) Cancer Symptom Trials (Gut Dysfunction Node; supported by Cancer Australia).
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Pathogenicity, modelling & treatment of inherited retinal Stargardt disease
Dr Di Huang is a Research Associate at the Lions Eye Institute (LEI), working with A/Professor Fred Chen and Dr Sam McLenachan. Her research focuses on developing a robust platform of retinal pigment epithelium cells and retinal organoids derived from patient-specific induced pluripotent stem cells to model inherited retinal diseases, particularly Stargardt disease (STGD1).
