MECHANISMS OF RESISTANCE TO MENIN INHIBITOR THERAPY AND ACUTE MYELOID LEUKAEMIA
With
Dr Rithin Nedumannil,
Consultant Haematologist and PhD Candidate,
Peter MacCallum Cancer Centre,
Austin Health,
Eastern Health,
Royal Melbourne Hospital
Melbourne, Australia
RESEARCHER PROFILE
Filmed in Melbourne, Australia | June 2025
Dr Rithin Nedumannil (MBBS, MPH, FRACP, FRCPA) is a PhD candidate at the University of Melbourne, undertaking his doctoral studies in collaboration with the Cambridge Stem Cell Institute (Cambridge, UK) and the Peter MacCallum Cancer Centre (Melbourne, Australia). He is a clinical haematologist and haematopathologist with current appointments at Peter MacCallum Cancer Centre, the Royal Melbourne Hospital, Austin Health and Northern Health.
After completing his medical degree at the University of Adelaide, Dr Nedumannil undertook advanced training in clinical and laboratory haematology across Melbourne’s major tertiary centres. He was awarded dual fellowships (FRACP and FRCPA) and went on to complete a subspecialty fellowship in Acute Leukaemia and Myelodysplastic Syndromes at Peter MacCallum Cancer Centre and the Royal Melbourne Hospital in 2024. He also holds a Master of Public Health from the University of New South Wales.
His interest in translational leukaemia research has been shaped by extensive clinical experience and academic work focusing on measurable residual disease, novel fusion genes and treatment resistance in acute leukaemias. His PhD will explore resistance mechanisms to menin inhibitors in acute myeloid leukaemia (AML) using genome-scale technologies including CRISPR screening, RNA sequencing and epigenomic profiling. His research will be conducted over two years at the Cambridge Stem Cell Institute and one year at Peter MacCallum Cancer Centre.
For this work, Dr Nedumannil has been awarded the 2025 Haematology Society of Australia and New Zealand and Leukaemia Foundation New Investigator PhD Scholarship, supporting his goal of translating molecular insights into improved therapeutic strategies for high-risk AML.
Source: Supplied
https://orcid.org/0000-0002-0883-3942
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New treatments for patients with mental illness
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Trials in treating STIs, vaccines and lipid lowering medications
Since joining Paratus Clinical Research in 2022, Dr Pi Lip Seet has served as both Principal Investigator and Sub-Investigator across Phase I–IV industry-sponsored clinical trials. His research experience spans vaccines, immunology, cardiovascular and endocrine disease, respiratory medicine, gastroenterology, pain management, sleep medicine and adult psychiatry. He has been involved in multiple vaccine development programs, including RSV, influenza, COVID-19, herpes zoster and pneumococcal studies.
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Pathogenicity, modelling & treatment of inherited retinal Stargardt disease
Dr Di Huang is a Research Associate at the Lions Eye Institute (LEI), working with A/Professor Fred Chen and Dr Sam McLenachan. Her research focuses on developing a robust platform of retinal pigment epithelium cells and retinal organoids derived from patient-specific induced pluripotent stem cells to model inherited retinal diseases, particularly Stargardt disease (STGD1).
