BIOLOGICAL INTERACTIONS OF EXTRACELLULAR VESICLES CONTRIBUTING TO METASTASIS OF BREAST CANCER AND OSTEOSARCOMA
Raluca Ghebosu, PhD Candidate
Australian Institute for Bioengineering and Nanotechnology
University of Queensland, Brisbane, Australia
RESEARCHER PROFILE
Filmed in Brisbane, Queensland, Australia | October 2024
Raluca Ghebosu graduated from the University of Queensland with a Bachelor of Arts/Bachelor of Science with majors in Japanese and Biomedical Science (2018-2021). She then completed her Bachelor of Science (Honours) with the School of Biomedical Sciences at the University of Queensland in 2022, before pursuing a PhD with A/Prof. Joy Wolfram at the Australian Institute for Bioengineering and Nanotechnology.
Raluca is currently exploring the complex biological interactions of extracellular vesicles, with the goal of understanding how they can contribute to the metastasis of breast cancer and osteosarcoma. She will do this by uncovering how extracellular vesicles from breast cancer and osteosarcoma cells allow the cancer cells to evade the immune system and avoid being detected by Natural Killer cells. By shedding light on the complex role of extracellular vesicles in cancer metastasis she hopes to revolutionise nanoparticle and cell-based cancer treatments.
Since beginning her PhD in 2023, Raluca has published two first author and two co-author manuscripts in high-ranking journals, including a first author paper in the premier journal of her field, Journal of Extracellular Vesicles (IF: 15.5), and has gained over 500 citations across her publications. She has presented her work to various audiences including scientists, clinicians and consumers and is a University of Queensland, 2024 3 Minute Thesis finalist. Raluca is also involved with the Wonder of Science Outreach program that promotes scientific inquiry and engagement to school-aged students across Queensland. Raluca hopes to continue being an advocate for STEM education and sharing her work with consumers and the broader scientific community
https://orcid.org/0000-0001-8839-3512
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Therapies for chronic myeloid leukaemia
Professor Tim Hughes is an international expert in the biology and treatment of leukaemia. He led the establishment of the molecular response criteria that are used world-wide to measure response in chronic myeloid leukaemia (CML) and has led many of the key Global and National trials. His group has successfully developed predictive bioassays and molecular targets that influence the way CML patients are managed world-wide. He has published over 350 papers that have been cited over 65,000 times.
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Causal genes and pathogenic mechanisms underlying gastrointestinal diseases
Professor D’Amato has more than 25 years research experience in the field of human genetics and complex diseases, with activities most recently geared towards a translational application for therapeutic precision in gastroenterology. His team, the Gastrointestinal Genetics Laboratory, combine leading expertise in genomic, computational and pre-clinical research, and have contributed important breakthroughs linking specific genes and pathogenetic mechanisms to a number of gastrointestinal diseases like inflammatory bowel disease (IBD), microscopic colitis (MC) and irritable bowel syndrome (IBS).
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Professor Christoph Hagemeyer
RESEARCH IN NANOBIOTECHNOLOGY
@ MONASH UNIVERSITY
VICTORIA, AUSTRALIA
